{"product_id":"abaloparatide-ba058-p1092","title":"Abaloparatide (BA058)","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eAbaloparatide (BA058, BIM-44058, ITM-058) is a novel 34-amino acid peptide selected to be a potent and selective activator of the parathyroid hormone receptor (PTH1R) signaling pathway with an IC50 of 0.117 nM in SOST analysis. The mapped target for this entry is Parathyroid hormone 1 receptor (PTH1R). This target context is most often investigated as part of ligand-responsive signaling, where receptor occupancy can reshape downstream second-messenger output, trafficking, secretion, excitability, or transcriptional programs. Across mechanistic studies, investigators commonly track acute pathway activation, receptor trafficking, and downstream transcriptional changes. This framing is especially useful when investigators want to connect a controlled ligand stimulus with rapidly changing cellular phenotypes.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eAs an agonist-format peptide, it is typically used to trigger pathway activation on demand and to compare acute signaling events with longer adaptive changes such as receptor desensitization or altered transcriptional output. In practice, dose-response design, timing, and matched control conditions are important for separating direct target engagement from delayed compensatory responses.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003epair peptide treatment with pathway-proximal signaling or trafficking readouts whenever possible\u003c\/li\u003e\n\u003cli\u003ecompare responses across cell states or model systems with different receptor abundance\u003c\/li\u003e\n\u003cli\u003edistinguish primary target engagement from downstream adaptation during longer incubations\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eExperimental interpretation should therefore connect early pathway changes with later phenotypic outputs, rather than relying on a single endpoint in isolation.\u003c\/p\u003e\u003ch2\u003eFormat Considerations\u003c\/h2\u003e\u003cp\u003eFor routine mechanistic work, the unmodified catalog format provides a consistent starting point for concentration-response studies, benchmark experiments, and orthogonal validation. In comparative workflows, consistency of preparation, exposure window, and matched controls is often as important as the nominal treatment itself. This is particularly helpful for comparative experiments, benchmark studies, and orthogonal validation in which small differences in formulation or handling can complicate interpretation. For peptide-centered workflows, conclusions are usually strongest when biological readouts are paired with consistent preparation and appropriately matched reference conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57636813439321,"sku":"P1092-5MG","price":215.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57636813472089,"sku":"P1092-25MG","price":645.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57636813504857,"sku":"P1092-100MG","price":1618.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/p1092-abaloparatide-2-chemical-structure.gif?v=1774212209","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/abaloparatide-ba058-p1092","provider":"Absource Diagnostics","version":"1.0","type":"link"}