{"product_id":"4-hydroxytamoxifen-afimoxifene-s7827","title":"4-Hydroxytamoxifen (Afimoxifene)","description":"\u003cp\u003e\u003cstrong\u003e4-Hydroxytamoxifen (Afimoxifene)\u003c\/strong\u003e is a modulator of Estrogen Receptor and Estrogen\/Progesterone Receptors used in studies of Hormone Signaling. It is especially relevant in cancer and endocrinology models, where defined compound exposure can be linked to ligand-dependent transcriptional programs and endocrine regulation.\u003c\/p\u003e\n\n\u003cp\u003eBy modulating Estrogen Receptor and Estrogen\/Progesterone Receptors, 4-Hydroxytamoxifen (Afimoxifene) can be used to examine ligand-dependent transcriptional programs and endocrine regulation. The nuclear receptor annotation adds relevance to reporter-gene, receptor-binding, and transcriptional assays, together with downstream-response mapping in the same experimental setting. In cancer and endocrinology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving Estrogen Receptor and Estrogen\/Progesterone Receptors\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Hormone Signaling\u003c\/li\u003e\n\u003cli\u003eContext-dependent response profiling and mechanism comparison\u003c\/li\u003e\n\u003cli\u003eReporter-gene, receptor-binding, and transcriptional assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, 4-Hydroxytamoxifen (Afimoxifene) is appropriate when a defined chemical perturbant is needed to connect Estrogen Receptor and Estrogen\/Progesterone Receptors with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and endocrinology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"10 mg","offer_id":57809545494873,"sku":"S7827-10MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57809545527641,"sku":"S7827-50MG","price":488.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57809545560409,"sku":"S7827-1G","price":2938.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809545593177,"sku":"S7827-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/s7827-4-hydroxytamoxifen-afimoxifene-chemical-structure.png?v=1776201908","url":"https:\/\/absource-diagnostics.myshopify.com\/products\/4-hydroxytamoxifen-afimoxifene-s7827","provider":"Absource Diagnostics","version":"1.0","type":"link"}